Cancer epidemiology among styrene-butadiene rubber workers.
Matanoski G; Francis M; Correa-Villasenor A; Elliot E; Santos-Burgoa C; Schwartz L
Butadiene and styrene: assessment of health hazards. Sorsa M; Peltonen K; Vainio H; Hemminki K, eds. IARC scientific publications, No. 127, Lyon, France: International Agency for Research on Cancer, 1993 Dec; :363-374
A case/control study was conducted on male workers from eight North American styrene/butadiene rubber manufacturing facilities to determine whether cases of lymphohematopoietic cancers in the industry could be explained by differences in worker exposure. Fifty nine cases of lymphohematopoietic cancer and 193 referents were chosen and compared. The work histories of the cases were obtained. A list of 464 jobs in 93 work subareas, 36 work areas, and ten subdivisions were reviewed, classified, and ranked according to the levels of styrene (100425) and butadiene (106990) exposure. The subjects were divided into four disease groups: leukemia, lymphatic cancers, lymphosarcomas, and Hodgkin's disease. An average exposure was calculated for each of the groups and subjected to logistic regression modeling. An increase in leukemia risk with increasing exposure score was indicated, and the findings were not changed by the use of cases validated by review of hospital records and selection of a new set of controls. Significant correlations between assigned ranks and exposure levels derived from personal monitoring were observed for only butadiene. It was suggested that the use of measured values might demonstrate an association between leukemia and butadiene exposure. The standardized mortality ratio for leukemia among long term employees hired before 1960 and working in facilities with butadiene levels three to five times higher than those in other facilities was nearly two times greater than that of the United States population. The authors conclude that the significance of the differences in job levels should be tested across facilities and time for the extrapolation and application of the data to the subjects in the original study.
NIOSH-Publication; NIOSH-Grant; Cancer; Aromatic-hydrocarbons; Butadienes; Cancer-rates; Employee-exposure; Epidemiology; Biostatistics; Rubber-manufacturing-industry; Rubber-workers; Styrenes
Epidemiology Johns Hopkins Universiyt 615 North Wolfe Street Baltimore, MD 21205
Sorsa M; Peltonen K; Vainio H; Hemminki K
Butadiene and styrene: assessment of health hazards
Johns Hopkins University, Baltimore, Maryland