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Documentation for immediately dangerous to life or health concentrations (IDLHs).
Ludwig HR; Cairelli SG; Whalen JJ
Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1994 May; :1-523
The sources of information and the criteria used to determine concentrations of various substances which have been deemed to be immediately dangerous to life and health (IDLHs) were reported. IDLHs were first established for 387 substances in the mid 1970s as part of the Standards Completion Program, which was a joint project of NIOSH and OSHA. The criteria and procedures used during the Standards Completion Program for establishing the IDLHs were considered, and the IDLHs were reviewed and revised. For each substance listed, information provided included any current exposure limits, the original IDLH, the basis for the original IDLH, acute toxicity data, human toxicity data, the revised IDLH, the basis for the revised IDLH, and references. The adequacy of each IDLH was determined based on a tiered approach. Human toxicity data were used preferentially, followed by acute animal inhalation toxicity data, and acute animal oral toxicity data. In the absence of relevant acute toxicity data, chronic toxicity data or toxicity data on an analogous chemical was used. Existing short term exposure guidelines and lower explosive limits were also considered. Current IDLHs can be found at: <a href="https://www.cdc.gov/niosh/idlh/"target="_blank">https://www.cdc.gov/niosh/idlh/</a>
NIOSH-Author; Acute-toxicity; Inhalants; Comparative-toxicology; Respiratory-protection; Lung-irritants; Worker-health; Exposure-limits
NTIS Accession No.
National Institute for Occupational Safety and Health
Page last reviewed: October 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division