Feasibility of a Cyclization-Based Method for the Determination of Thionyl Chloride in Air.
NIOSH 1995 Jan:28 pages
An attempt was made to develop a method for the determination of thionyl-chloride (7719097) in the workplace air, based on reacting thionyl-chloride with a reagent to form a cyclization product. Using this approach, a unique cyclization product would be formed which could then be separated from its precursor and other interferents and quantitated. The tested reagents included 1,8- diaminonaphthalene, 8-amino-1-naphthol, and 2-hydroxymethyl- piperidine. The results of the study indicated that it was not feasible to develop a method for determining thionyl-chloride using these reagents. With 1,8-diaminonaphthalene there was no evidence of a cyclization reaction product formed with thionyl-chloride. The desired cyclization product was formed with 8-amino-1-naphthol, but the reaction could not effectively compete against the oxidation of the starting material. For the 2-hydroxymethyl-piperidine reagent, there was evidence of a cyclization product, but that product did not appear to be stable under normal conditions.
NIOSH-Author; Analytical-methods; Chemical-reactions; Chlorides; Air-quality-monitoring; Chemical-analysis; Analytical-chemistry;
NTIS Accession No.
Division of Physical Sciences and Engineering, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio, 28 pages, 9 references