NIOSHTIC-2 Publications Search

Does regression analysis of lung function data obtained from occupational epidemiologic studies lead to misleading inferences regarding the true effect of smoking?

Authors
Attfield MD; Hodous TK
Source
Am J Ind Med 1995 Feb; 27(2):281-291
NIOSHTIC No.
00225226
Abstract
The distribution of forced expiratory volume in 1 second (FEV1) measurements in a cohort of working coal miners was examined to test the hypothesis that a subgroup of data exerted undue effects on the findings related to smoking. Medical data on ventilatory function, chest symptoms, age, height, occupational and smoking history for 7,154 miners, from the first round of the National Study of Coal Workers' Pneumoconiosis were analyzed. Dust exposure estimates calculated for each miner were based on job specific dust concentration estimates from an industrial hygiene survey and converted to units of gram hour/cubic meter. FEV1 was correlated to smoking and dust exposure through linear regression analysis. The analysis of influential observations was conducted through the use of several described methods. Basic statistics on lung function, anthropometric data, and cumulative dust exposure were presented. Regression estimates of the smoking effect showed clear effects of smoking and dust exposure. A graphical analysis was conducted due to the lack of substantial results from the analysis of influential observations. The FEV1 deviation distributions for smokers and nonsmokers were compared by age group, with similar results as those seen for the previous analysis. A suggestion of skewness was present for smokers in the oldest age group, but it was not found to be significant. The authors conclude that the current method of comparing smoking and dust exposure coefficients calculated through regression analysis of lung function data is valid and nonmisleading.
Keywords
NIOSH-Author; Statistical-analysis; Coal-miners; Lung-function; Cigarette-smoking; Dust-exposure; Mine-workers; Pulmonary-function-tests; Epidemiology; Occupational-exposure; Author Keywords: lung function; coal mining; smoking; linear regression; dust exposure; health effects
Contact
Michael D. Attfield, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., Morgantown, WV 26505
CODEN
AJIMD8
Publication Date
19950201
Document Type
Journal Article
Fiscal Year
1995
Issue of Publication
2
ISSN
0271-3586
NIOSH Division
DRDS
Source Name
American Journal of Industrial Medicine
State
WV
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division