The relationship between bone lead and hemoglobin.
Hu-H; Watanabe-H; Payton-M; Korrick-S; Rotnitzky-A
JAMA J Am Med Assoc 1994 Nov; 272(19):1512-1517
A cross sectional investigation was conducted in which blood lead (7439921) and bone lead levels among workers with only moderate lead exposure histories were related to blood pressure and indicators of renal function and hematologic status. The 119 study subjects were members of the construction trade union involved in carpentry, demolition and other construction activities. In-vivo bone lead measurements were made using K-X-ray fluorescence. Blood pressure was measured, and blood samples were analyzed for blood lead, hemoglobin, hematocrit, serum uric-acid, and serum creatinine. Bone lead levels were low and not correlated with either hemoglobin or hematocrit. An increase in patella bone lead levels from the lowest to highest quintile in this study population was associated with a decrease in hemoglobin and hematocrit of 11 grams/liter and 0.03, respectively. The authors conclude that this is the first epidemiological study to suggest that bone lead exerts subclinical toxicity in a population of apparently normal workers with low blood lead levels.
NIOSH-Publication; NIOSH-Grant; Training; Blood-analysis; Lead-poisoning; Kidney-damage; Heavy-metal-poisoning; Epidemiology; Risk-factors; Construction-workers; Blood-pressure; Body-burden
Dr Hu, Channing Laboratory, 180 Longwood Ave, Boston, MA 02115
Journal of the American Medical Association
Harvard University, Boston, Massachusetts