A possible role for glutathione transferase mu in susceptibility to asbestos related pulmonary disease.
Smith CM; Christiani DC; Kelsey KT
Proceedings of the 9th international symposium on epidemiology in occupational health. Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 94-112, 1994 Jan; :523-534
Glutathione-S-transferase mu (GST-mu) activity in asbestos (1332214) induced lung disease was examined. The study cohort included 87 adult workers, 77 of whom had asbestos related diseases (ARD). Pleural disease was present in 40 individuals and a diagnosis of asbestosis was rendered in 37. Ten persons with other pulmonary diseases were included, diagnosed with pneumonia, emphysema, or other respiratory complaints with no history of ARD. Primary disease classifications included asbestos related pulmonary disease (ARPD) and asbestosis. Employment histories were taken and estimates made of the exposure levels. The GST activities in the group ranged from 0 to 1,864 picomoles product/minute/10(7) cells. Activities less than 75 picomoles product/minute/10(7) cells were demonstrated by 28 of the study subjects. Activities greater than 200 were recorded for 28 of the subjects. Of those exhibiting ARPD, 44 (57%) were GST-mu negative. While not statistically significant, the findings suggest that GST-mu deletion may be over represented among those with ARD. No difference was noted in GST-mu status between individuals exhibiting asbestos pleural disease only versus those with parenchymal asbestosis. The authors suggest that GST-mu may be associated with increased susceptibility to asbestos induced lung disease. They note that this possibility is consistent with proposed mechanisms of asbestos toxicity.
Asbestos-fibers; Lung-irritants; Lung-cells; Epidemiology; Lung-cancer; Cancer-rates; Risk-factors; Enzyme-activity
Proceedings of the 9th international symposium on epidemiology in occupational health