The epidemiology of populations exposed to dioxin.
Fingerhut MA; Sweeney MH; Halperin WE; Schnorr TM
Environmental carcinogens: methods of analysis and exposure measurement. Volume 11. Polychlorinated dioxins and dibenzofurans. Rappe C, Buser HR, Dodet B, O'Neill IK, eds. Lyon: International Agency for Research on Cancer, IARC Scientific Publications No. 108, 1991 Jan; 11:31-50
This review of epidemiological studies of workers and nonworkers exposed to chlorophenols and phenoxy herbicides, and their dioxin contaminants, focused on the parameters as well as the outcomes of the studies. Reports from the period 1937 to 1979 were summarized briefly; most consisted of qualitative accounts of specific health effects on workers exposed to these compounds routinely or through chemical factory explosions. Recent studies were classified according to the type of study conducted; limitations of each study (statistical significance, assessment of actual exposure, latent periods) were noted. The types of reports reviewed were cohort, case/control, reproductive outcome, cross sectional medical studies, and those using national census data. These studies generally involved workers in the chemical industry, those involved in pesticide application, and Vietnam veterans. The authors conclude that some individuals develop chloracne as a result of exposure to dioxins. Industrial workers exposed to dioxin contaminated substances exhibit peripheral neuropathy, cardiovascular disease, liver dysfunction and other acute consequences. Although some studies determined exposure to phenoxy herbicides and chlorophenols to be associated with various cancers, no definitive conclusion can be made about their possible carcinogenic effects or other medical risks.
NIOSH-Author; Neurotoxic-effects; Hepatotoxicity; Skin-disorders; Chemical-industry-workers; Agricultural-industry; Chlorophenoxy-herbicides; Chlorinated-phenols; Occupational-exposure; Military-personnel; Toxic-effects
Rappe C; Buser HR; Dodet B; O'Neill IK
Environmental carcinogens: methods of analysis and exposure measurement. Volume 11. Polychlorinated dioxins and dibenzofurans