Asthma experience in an occupational and environmental medicine clinic. Low-dose reactive airways dysfunction syndrome.
Kipen-HM; Blume-R; Hutt-D
J Occup Med 1994 Oct; 36(10):1133-1137
Asthma prevalence in an occupational and environmental medicine clinic was investigated with special reference to the incidence of low dose reactive airways dysfunction syndrome (RADS). All asthma cases referred to the clinic over the 5 year period July 1986 to July 1991 were reviewed. Evaluations consisted of complete medical, occupational, and environmental history, as well as physical examination, and diagnostic procedures when indicated, for confirmation of reversible obstructive airways disease. Cases were reviewed to ascertain the proven or suspected causes, and where known exposure to a bronchial irritant preceded the onset on asthma within 24 hours, the case was categorized as RADS. The data from 200 cases were analyzed. Results showed that common diagnoses were asbestosis, silicosis, repetitive motion syndrome, peripheral neuropathy, and chemical sensitivity syndrome. The diagnostic criteria of asthma were fulfilled by 32 cases, of whom five had an earlier history. The 27 cases left were strictly new adult onset cases. Seven represented RADS. Ten cases of nonsensitization adult onset asthma in settings of exposure to noticeable, but distinctly tolerable, levels of inhalation irritants were found. These represented 31% of the verified asthma cases. The authors conclude that there is an association between recurrent low dose exposure and the development of adult onset asthma.
NIOSH-Publication; NIOSH-Grant; Training; Air-contamination; Epidemiology; Lung-irritants; Occupational-exposure; Bronchial-asthma; Humans; Respiratory-hypersensitivity
Community Medicine Mount Sinai School of Medicine One Gustave L Levy Place Bx108 New York, NY 10029
Journal of Occupational Medicine
Mount Sinai School of Medicine, New York, New York