Cell kinetics in the respiratory tract of hamsters exposed to cigarette sidestream smoke.
Inhal Toxicol 1994 Jul; 6(4):321-333
The effects of exposure to sidestream smoke on cellular proliferation in the respiratory tract were examined. Syrian-Golden-hamsters were exposed to sidestream cigarette smoke for up to 3 weeks and examined at various times after cessation of smoke exposure for evidence of pathology and bromodeoxyuridine (BrdU) labeling of terminal bronchioles, intrapulmonary large airways, tracheae, and nasal passages. No histological abnormalities attributable to smoke exposure were observed in any of the animals. A significantly increased BrdU labeling index in the respiratory epithelium lining the nasal septum was seen during the first week of smoke exposure. The BrdU labeling indices in the terminal bronchioles of animals who had been exposed for 1 week and allowed to recover for a second week were significantly higher than those seen in animals that were exposed for 1 week and examined immediately thereafter. The labeling indices in the maxillary turbinates in these animals were, however, significantly lower than those of controls and animals who had been exposed to smoke for 2 weeks and allowed to recover for 1 week. The authors conclude that these results demonstrate minimal yet definitive evidence of a biological response to the inhalation of sidestream smoke.
Cigarette-smoking; Smoke-inhalation; Toxic-effects; Cell-growth; Lung-cells; Biological-effects; Pulmonary-system; Inhalation-studies; Respiratory-irritants
University of California - Davis