Effect of Exercise on the Pulmonary Cellular Response to Inhalation of Cotton Dust.
Authors
Frazer DG; Robinson VA; Barger MW; Jones TA; Higgins H; Keating J; VanDyke C; Weber KC; Castranova V
Source
1993 Proceedings, Beltwide Cotton Conferences, New Orleans, Louisiana, January 10-14, 1993, National Cotton Council of America, Memphis, Tennessee 1993:252-254
Link
NIOSHTIC No.
00221455
Abstract
The effect of exercise performed while running on a treadmill on the pulmonary cellular response of rats to cotton dust was examined. Exercised rats, conditioned over a 4 week period, were exposed to cotton dust at 6.1mg/m3 or filtered air as they periodically performed exercise on a treadmill. Cellular response was measured 6 hours postexposure and compared with the cellular response of nonconditioned, nonexercising rats exposed to similar dust levels or filtered air. The exercised, conditioned rats exposed to cotton dust had a slight but significantly greater cellular response than either sedentary rats or conditioned rats exposed to filtered air. No significant difference was noted in the total number of cells recovered between conditioned rats intermittently exercised and sedentary rats when both were breathing filtered air. No significant difference was noted in the number of macrophages recovered in each of the four groups of rats. The macrophages from the exercised rats were able to produce more superoxide than macrophages from resting rats exposed to similar dust levels. The authors suggest that increased deposition, or alteration of the distribution or clearance of cotton dust particles in the lungs during exercise appears to increase the toxicity of cotton particles in the rat lung.
Links with this icon indicate that you are leaving the CDC website.
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
You will be subject to the destination website's privacy policy when you follow the link.
CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website.
For more information on CDC's web notification policies, see Website Disclaimers.
CDC.gov Privacy Settings
We take your privacy seriously. You can review and change the way we collect information below.
These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. They help us to know which pages are the most and least popular and see how visitors move around the site. All information these cookies collect is aggregated and therefore anonymous. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance.
Cookies used to make website functionality more relevant to you. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests.
Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data.
Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. These cookies may also be used for advertising purposes by these third parties.
Thank you for taking the time to confirm your preferences. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page.