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Effect of Exercise on the Pulmonary Cellular Response to Inhalation of Cotton Dust.

Frazer DG; Robinson VA; Barger MW; Jones TA; Higgins H; Keating J; VanDyke C; Weber KC; Castranova V

1993 Proceedings, Beltwide Cotton Conferences, New Orleans, Louisiana, January 10-14, 1993, National Cotton Council of America, Memphis, Tennessee 1993:252-254

00221455

The effect of exercise performed while running on a treadmill on the pulmonary cellular response of rats to cotton dust was examined. Exercised rats, conditioned over a 4 week period, were exposed to cotton dust at 6.1mg/m3 or filtered air as they periodically performed exercise on a treadmill. Cellular response was measured 6 hours postexposure and compared with the cellular response of nonconditioned, nonexercising rats exposed to similar dust levels or filtered air. The exercised, conditioned rats exposed to cotton dust had a slight but significantly greater cellular response than either sedentary rats or conditioned rats exposed to filtered air. No significant difference was noted in the total number of cells recovered between conditioned rats intermittently exercised and sedentary rats when both were breathing filtered air. No significant difference was noted in the number of macrophages recovered in each of the four groups of rats. The macrophages from the exercised rats were able to produce more superoxide than macrophages from resting rats exposed to similar dust levels. The authors suggest that increased deposition, or alteration of the distribution or clearance of cotton dust particles in the lungs during exercise appears to increase the toxicity of cotton particles in the rat lung.

Laboratory-animals; Physical-exercise; Cotton-dust; Dust-inhalation; Lung-cells; Cellular-reactions; Inhalation-studies;

19930101

Conference/Symposia Proceedings;

1993

1993 Proceedings, Beltwide Cotton Conferences, New Orleans, Louisiana, January 10-14, 1993, National Cotton Council of America, Memphis, Tennessee

LA; TN;