Does cotton bract extract challenge cause "Monday" bronchospasm?
Schachter-EN; Russomanno-J; Siegel-J; Fine-E; Rienzi-N; Witek-TJ Jr.; Buck-MG; Godbold-J
1993 Proceedings, Beltwide Cotton Conferences, New Orleans, Louisiana, January 10-14, 1993, National Cotton Council of America, Memphis, Tennessee 1993:279-280
In an effort to further validate the usefulness of an in-vivo human model, a study was designed to investigate whether or not the bronchial reactions elicited by cotton bracts were similar to the clinically described Monday dyspnea of textile workers. Twenty seven healthy nonsmokers aged 18 to 40 years participated in the study. The subjects were exposed to cotton bract extract (CBE) inhalation on 5 consecutive days and on day eight, following a 2 day break from exposure. Lung function tests were performed before and after CBE challenge; methacholine responsiveness was measured 2 hours after CBE challenge. There were acute decrements in expiratory flow rates following CBE inhalation among healthy nonsmoking volunteers who had never been exposed to CBE. Daily decrements were noted in expiratory flow rate following inhalation of CBE on 5 consecutive days and these were greatest on the first day. After a 2 day interruption of daily CBE inhalation, the CBE induced decrements in expiratory flow rates returned to levels noted on the first day. Monday bronchospasm was restricted to responders (individuals sensitive to CBE). Responders exhibited significantly increased airway reactivity with the Monday bronchospasm.
NIOSH-Grant; Pulmonary-system-disorders; Cotton-dust; Organic-dusts; Plant-dusts; Respiratory-system-disorders; Lung-irritants; Humans; Pulmonary-function-tests
Medicine Mount Sinai Medical Center One Gustave L Levy Place New York, N Y 10029
1993 Proceedings, Beltwide Cotton Conferences, New Orleans, Louisiana, January 10-14, 1993, National Cotton Council of America, Memphis, Tennessee
Mount Sinai School of Medicine, New York, New York