Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1993 Jul; :1-22
Research needs and research strategies for identifying and preventing lung disease resulting from occupational fiber exposure were developed. The report established research priorities and described the various types of research on fibers, including asbestos (1332214). Research areas discussed included fiber characterization, fiber analysis, biological activity, mechanisms of disease, epidemiological investigations, and control methods. Within the area of biological activity and mechanisms of disease, topics included the need for dose response relationships, role of radicals in pathogenesis, animal short and long term exposure studies, in- vitro exposure studies, genotoxicity, and biomarkers. Epidemiological research areas considered included characterization of exposure, nonasbestiform fibers, mineral and synthetic fibers, pulmonary fibrosis and carcinogenesis, other neoplasms, updating studies, and biological markers. Control methods included substitution of materials, new or modified controls, development of new substitute products, and protective clothing. Research strategies discussed included the need for disease mechanism research, the role of epidemiological studies in assessing human risk, the role of in-vivo and in-vitro studies, integration of various studies, and research priorities.