A study of industries and occupations at high risk for work related homicide was conducted. The National Traumatic Occupational Fatalities database was searched to identify all work related homicides that occurred from 1980 through 1989. The industry and occupation of the victims were determined from entries in the designated blocks in the death certificate. A total of 7,581 work related homicides occurred during the study period. This yielded an annual incidence rate of 0.71 homicides per 100,000 workers. Approximately 80% of the homicides were to males. When stratified by race, the work related homicide rate for black workers, workers of other races, and white races was 1.42, 1.57, and 0.60 per 100,000, respectively. Nearly 30% of all work related homicides occurred in grocery stores, eating and drinking places, and in the justice, public order, and safety industry. Among individual occupations, taxicab drivers had the highest homicide rate, 26.9 per 100,000. This rate was nearly 40 times greater than the rate for all workers and more than three times greater than the rate for liquor store employees, the occupation with the next highest rate. The work related homicide rate for males exceeded that for females in all industries where a rate for females could be calculated. The homicide rate for nonblack workers exceeded the rate for blacks in only two: justice, public order, and safety; and hotels and motels. When stratifying the homicide rate in occupations by gender, the rates for males exceeded those for women except for stock handlers and baggers. The authors conclude that the study has indicated that homicide in the workplace is an occupational health problem of significant proportions.