The association between occupational exposure to 2,3,7,8- tetrachlorodibenzo-p-dioxin (1746016) (TCDD) contaminated chemicals and porphyria cutanea tarda, uroporphyrinuria, and coproporphyrinuria was examined in 281 former chemical workers. An unexposed comparison group of 260 age, race, and sex matched individuals was recruited from the neighborhoods where the workers lived. The study cohort members had been employed more than 15 years earlier in the manufacture of sodium-trichlorophenol (136323), 2,4,5-trichlorophenoxyacetic-ester, or hexachlorophene (70304). The workers had a statistically significantly elevated mean serum TCDD level of 220 picograms/gram of lipid compared to a mean level of 7 picograms/gram of lipid in the comparison group. None of the participants demonstrated symptomatic porphyria cutanea tarda. Subclinical porphyria cutanea tarda was found in three workers and three comparisons. Urinary uroporphyrin and urinary coproporphyrin levels showed no statistically significant differences between the workers and the comparisons. Logistic regression analysis failed to show a significant association between the risk of range urinary uroporphyrin or coproporphyrin levels and any measure of TCDD exposure. The authors conclude that there was not sufficient evidence to convincingly support or refute an association between TCDD exposure and porphyria cutanea tarda or porphyrinuria.
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