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Neurologic Effects of Solvents in Older Adults. The "UW Retired Worker Study."
Daniell-WE; White-D; Claypoole-K; Dager-S; Townes-B; Smith-Weller-T; Checkoway-H; Rosenstock-L
Occupational Medicine Programs, Department of Medicine, University of Washington, Seattle, Washington 1993 Nov:110 pages
The possibility that previous occupational exposure to solvents might be associated with clinically significant neurological dysfunction in older adults was investigated in a cross sectional study. Subjects included 67 painters, 22 aerospace painters and fuel cell sealers, and a comparison group of 126 carpenters. All subjects had retired from regular employment at least 1 year prior to the study. As measured by semiquantitative exposure index, the cumulative histories of lifetime occupational solvent exposure were on the average comparable in the two exposed study groups, painters and aerospace workers. The carpenters differed from the other groups in solvent exposure by several orders of magnitude. The painters had a significantly higher history of consuming alcoholic beverages than did the other two study groups. The painters had a significantly higher score on the Beck Depression Inventory, a measure of current depressive symptoms. The painters reported significantly more general neurologic symptoms than did the other two groups. The aerospace workers showed much greater evidence of possible adverse effects from former solvent exposure on current neuropsychological function than did the painters when determined by reasoning and memory tests, memory visual motor speed and motor tests. No evidence of persistent effects on liver or renal excretory function was seen in solvent exposed subjects.
Neurotoxic-effects; Organic-solvents; Solvent-vapors; Nervous-system-disorders; Painting; Aerospace-workers; Woodworking-industry; Occupational-exposure
Medicine Harbrview Medical Ctr 325 9Th Ave Seattle, WA 98104
Final Grant Report
NTIS Accession No.
Neurotoxic Disorders; Neurotoxic-effects
Occupational Medicine Programs, Department of Medicine, University of Washington, Seattle, Washington
University of Washington, Seattle, Washington
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division