Sister-chromatid exchanges in lymphocytes are increased in relation to longitudinally measured occupational exposure to low concentrations of styrene.
Yager-JW; Paradisin-WM; Rappaport-SM
Mutat Res 1993 Nov; 319(3):155-165
A study was conducted on the dose response relationship between styrene (100425) exposure and the induction of genotoxicity. Blood samples were obtained from workers in a boat manufacturing facility and the presence of sister chromatid exchanges and micronuclei in lymphocytes and styrene and styrene-glycol concentrations in the blood were determined. Occupational exposures to styrene were monitored as well over the course of 1 year. The highest exposure levels were seen in laminators, chopper gun operators, and mold repairers. Linear regression analyses demonstrated that the incidence of sister chromatid exchanges was significantly increased in cigarette smokers and in those exposed to a mean air concentration of styrene of 64.2mg/m3. It was estimated that about 25% of the variability in sister chromatid exchanges seen in this cohort could be accounted for by exposure to styrene and 62% by cigarette smoking. No effects of styrene exposure on the frequency of micronuclei were seen.
NIOSH-Publication; NIOSH-Grant; Grants-other; Genotoxic-effects; Occupational-exposure; Cigarette-smoking; Dose-response; Boat-manufacturing-industry;
Author Keywords: Sister-chromatid exchange; SCE; Micronuclei; MN; Cytokinesis-block; Lymphocytes; Styrene; Low-level exposure; Longitudinal; Occupational exposure; Intra- and inter-individual MN; Gender; Age
Biomedical & Environ Hlth Scis University of California School of Public Health Berkeley, CA 94720
Other Occupational Concerns
University of California Berkeley, Berkeley, California