A study was conducted on hazards to farm workers associated with the use of anhydrous-ammonia (7664417). The agricultural applications of anhydrous ammonia and the recommended exposure limits were discussed. A Hazard and Operability (HAZOP) analysis was conducted by NIOSH to evaluate hazards associated with the storage, transfer, and application of anhydrous-ammonia. Four categories with a total of 95 findings were identified in the HAZOP analysis. Up to 40% of the findings were contained in the category of training and procedure, 31% were in the equipment design category, 22% in maintenance and inspection, and 7% in material compatibilities. Specific findings included a need for increased awareness on the part of operators to dangers and how hazardous situations develop, a need for changes in the design of the quick disconnect attaching the tank hose to the toolbar hose, a need for changes in maintenance procedures, and a need for attention to the composition of pipes and relief valves used for ammonia operations. The findings of this HAZOP were incorporated into information sheets for distribution to farmers, retail distributors, and equipment manufacturers.