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Health hazard evaluation report: HETA-89-0343-2348, Florida Hospital, Orlando, Florida.
Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, HETA 89-0343-2348, 1993 Sep; :1-28
In response to a request from the hospital management, a study was made regarding employee exposure to aerosolized ribavirin (36791045) at Florida Hospital (SIC-8062) located in Orlando, Florida. Concern was voiced about several spontaneous abortions which had occurred in nurses working on the pediatric floor. Employee exposures to aerosolized ribavirin were documented and an epidemiologic study to test for an association between occupational exposure to ribavirin and the occurrence of either spontaneous abortion or decreased fertility was also begun. There were 273 completed reproductive questionnaires returned (52% response rate). There were only 64 pregnancies during the time when ribavirin was in use, three of which ended in a spontaneous abortion. Of 22 pregnancies in women with ribavirin exposure, only one ended in spontaneous abortion. No meaningful statistical analysis was possible due to the small number of spontaneous abortions reported. In a comparison of the reported number of cycles needed to achieve pregnancy, there was no difference between those women exposed to ribavirin at the time they were trying to conceive and those who were not so exposed. The author concludes that it was not possible to draw any conclusions about the risk of spontaneous abortion associated with occupational exposure to ribavirin.
NIOSH-Author; NIOSH-Health-Hazard-Evaluation; NIOSH-Technical-Assistance-Report; HETA-89-0343-2348; Hazard-Unconfirmed; Region-4; Reproductive-system-disorders; Health-care-personnel; Nursing; Occupational-exposure; Pharmaceuticals; Reproductive-hazards; Author Keywords: General Medical and Surgical Hospitals; ribavirin; Virazole; 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboximide; aerosolized drugs; aerosolized pharmaceuticals; health care workers; aerosol containment system; spontaneous abortion; reproduction
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