An evaluation was performed to assess the feasibility of the neurobehavioral core test battery (NCTB) for testing subjects in diverse international populations. Subjects participated in the study in ten countries including countries in Europe, North and Central America, and Asia for a total of over 2,300 subjects who were not exposed to chemicals at their places of work and who ranged in age from 16 to 65 years. While there were clearly differences in mean performance between countries on many tests, within country performance across age ranges was remarkably consistent in the six countries in which such data were obtained. Feasibility was thus demonstrated for a range of cultural groups as long as within country comparisons were planned. The authors indicate that the NCTB can be used widely, perhaps universally, in male and female working age populations with 8 to 12 years of formal education, as long as the education variable is equated among groups or included in the data analysis. The degree for which subjects with less than 8 years of education can provide baseline performance on most NCTB tests that will allow detection of neurotoxic effects in exposed populations remains an open question.