The relationship between HLA-A, B, DQ, and DR antigens and asbestos- induced lung disease.
Shih-F; Hunninghake-GW; Goeken-NE; Galvin-JR; Merchant-JA; Schwartz-DA
Chest 1993 Jul; 104(1):26-31
A study of the relationship between human leukocyte antigen (HLA) phenotype and asbestos (1332214) induced lung disease was conducted. The study group consisted of 42 white males, mean age 58.8 years, being evaluated for asbestos related lung disease. They had been occupationally exposed to asbestos for a mean of 33.7 years. HLA typing was performed utilizing T-lymphocytes and B-lymphocytes. Fifteen subjects had radiographic evidence of asbestosis and 18 had asbestos induced pleural fibrosis. The prevalence of the HLA-A29 antigen was significantly increased in subjects with asbestosis compared to those with normal chest X-rays, 26.7 versus 3.7%. The prevalence of HLA-B44 and HLA-Bw4 antigens was also significantly increased in the asbestotic subjects. The prevalence of HLA-B27 was only slightly increased in the asbestotic subjects. The prevalence of HLA-29, HLA-B44, and HLA-Bw4 was not significantly associated with the severity of asbestosis, asbestosis latency, or duration of asbestos exposure. Pleural fibrosis was only marginally significantly associated with two antigens, HLA-DRw53 and HLA-DQ2. The prevalence of HLA-DQ2 was significantly associated with the presence of unilateral and circumscribed plaques on the chest X-ray film. The prevalence of HLA-DRw53 and HLA-DQ2 was not significantly associated with pleural fibrosis severity or latency or duration of asbestos exposure. Except for a correlation between decreased residual volume and the presence of HLA-A29 antigen, no significant associations between the HLA phenotypes and pulmonary function were detected. The authors suggest that the occurrence of the HLA-A29 phenotype may be associated with asbestosis and the HLA-DQ2 phenotype with asbestos related pleural fibrosis. The fact that these associations are not particularly strong and have not been observed in previous studies suggests that the HLA complex does not play an important role in the development of asbestos related lung disease.
NIOSH-Grant; Pulmonary-system-disorders; Asbestos-workers; Lymphocytes; Genetic-factors; Chest-X-rays; Immune-system
Internal Medicine University of Iowa Pulmonary Disease Division Iowa City, IA 52242
Pulmonary System Disorders
University of Iowa, Iowa City, Iowa