Case control study of cancer in synthetic rubber workers.
Matanoski-GM; Correa-Villasenor-A; Francis-M; Elliott-EA
School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 1993 May; :1-30
A nested case/control study was conducted of gastrointestinal cancer in male workers from eight styrene-butadiene polymer manufacturing facilities in the United States and Canada to determine whether there was any association with exposures to styrene (100425) and butadiene (106990). A study on the association between hematologic neoplasms and exposure to butadiene and styrene was reexamined using different criteria for matching and exposure. Exposure levels for each job in the industry were developed, based on area and personal monitoring. The risk of lymphohematopoietic cancers was increased in the workers who had increased exposure to butadiene. Even using different methodologies such as choosing different types of controls, the risk of leukemia among these workers remained high. Among the leukemia cases, there was a higher than expected proportion of acute lymphocytic leukemia. Some of the odds ratios were high for butadiene and styrene associated with esophageal cancers, but the findings were not statistically significant. Also not significant was a suggestive trend for increasing odds ratios with increasing butadiene exposure for colorectal cancers. When short term workers were included, there was an increase in the all cause mortality, but no increase in standardized mortality ratios for cancer or circulatory diseases. Long term workers had higher risks for cancers of interest in this study than short term workers.
NIOSH-Grant; Cancer; Leukemogenesis; Cancer-rates; Risk-factors; Mortality-surveys; Occupational-exposure; Epidemiology; Synthetic-rubber-manufacturing; Gastrointestinal-system-disorders
Epidemiology Johns Hopkins Universiyt 615 North Wolfe Street Baltimore, MD 21205
Final Grant Report
NTIS Accession No.
School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland
Johns Hopkins University, Baltimore, Maryland