A laboratory model of sick building syndrome.
Frank-R; Davidoff-LL; Guilarte-T; Paquette-N; Weinmann-G
Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 1992 Dec; :1-37
The goal of this study was to develop a laboratory model of Sick Building Syndrome (SBS). Preliminary studies were conducted concerning the fractional uptake and excretion of volatile organic compounds (VOCs). Techniques were developed and tested for correlating the effects of VOCs on the composition of tear fluid and symptoms of eye irritation as eye irritation is a frequently reported symptom of SBS. Lactic-dehydrogenase, total proteins, and differential cell counts of polymorphonuclear leukocytes, macrophages, and epithelial cells were studied as markers in tear fluid. The effects of VOCs on the performance of neurobehavioral tasks were also investigated. Subjects were exposed to a total VOC concentration of 20mg/m3 or less in an exposure chamber, and administered cognitive tests, including a grammatical reasoning task and a switching direction task. The test/retest reliability of cerebral glucose metabolism measurements was established for a dual detector probe system for monitoring metabolism in the central nervous system.
NIOSH-Grant; Psychological-disorders; Indoor-air-pollution; Organic-compounds; Closed-building-syndrome; Air-quality-monitoring; Eye-irritants; Eye-disorders; Respiratory-system-disorders; Neurotoxic-effects; Indoor-environmental-quality
Environmental Health Sciences Johns Hopkins University 615 North Wolfe Street Baltimore, MD 21205
Final Grant Report
NTIS Accession No.
Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland
Johns Hopkins University, Baltimore, Maryland