NIOSHTIC-2 Publications Search
Neurologic and Behavioral Disorders.
Occupational Health, Recognizing and Preventing Work-Related Disease, Second Edition. Levy BS, Wegman DH, eds., Boston: Little, Brown and Company, 1988 Jan; :399-413
Occupationally related neurological and behavioral disorders were reviewed. The problem of neurotoxicant exposures in the workplace was discussed and illustrated by a case history of a chemical industry employee who developed neuropsychological problems due to exposure to mercury (7439976). The pathophysiology of peripheral (PNS) and central nervous system (CNS) disorders was reviewed. The most prominent features of PNS damage consist of segmental demyelination and axonal degeneration of nerve fibers. CNS damage typically results from disruption of neurotransmitter metabolism and inhibition of synaptic transmission. Agents that induce pathological changes in the PNS included lead (7439921), chlordecone (143500), and carbon-monoxide (630080). Agents that attack both the PNS and CNS included acrylamide (79061), n-hexane (110543), methyl-n- butyl-ketone (591786), carbon-disulfide (75150), tri-ortho-cresyl- phosphate (78308), and other organophosphorus compounds. The clinical aspects of behavioral disorders by neurotoxic agents were discussed. Exposure to industrial neurotoxicants can result in a wide spectrum of effects ranging from mild fatigue to overt psychoses. Recent memory appeared to be the cognitive function most effected by neurotoxicant exposure. The diagnosis and management of occupationally induced neurologic disorders were considered. The neuropathological effects of lead, mercury, organophosphate insecticides, and organic solvents were reviewed. Mass psychogenic illness and its diagnosis and management were discussed.
Central-nervous-system; Peripheral-nervous-system; Neurotoxicity; Organic-solvents; Psychological-disorders; Occupational-diseases; Clinical-diagnosis; Heavy-metals; Case-studies; Neuropathology
7439-97-6; 7439-92-1; 143-50-0; 630-08-0; 79-06-1; 110-54-3; 591-78-6; 75-15-0; 78-30-8
Book or book chapter
Psychologic Disorders; Psychological-disorders
Occupational Health, Recognizing and Preventing Work-Related Disease, Second Edition
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division