A novel approach to the characterization of cumulative exposure for the study of chronic occupational disease.
Seixas-NS; Robins-TG; Becker-M
Am J Epidemiol 1993 Feb; 137(4):463-471
A novel exposure metric was considered which accounts for the effects of both the concentration of a toxic agent in the work environment and for the time between exposure and the measurement of outcome. The model was simple to use. It was also flexible enough to allow a broad range of related possible models to be considered. The model was used to examine a previously studied cohort of coal miners with obstructive lung disease. The analysis was restricted to 1,185 miners for whom complete quantitative exposure histories were constructed. The work histories indicated these individuals had worked for 12.8+/-3.4 years and had a simple cumulative exposure of 15.6+/-6.5mg/m3. Exposure response analysis indicated a statistically significant association of dust exposure with forced expiratory volume in 1 second and elevated odds of wheeze. The findings suggested that when exploring exposure response models, investigators should carefully consider the robustness of the particular model chosen by changing the parameterization of their models and observing the resulting change in model fit.
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Coal-dust; Chronic-exposure; Respiratory-system-disorders; Underground-mining; Coal-miners; Epidemiology; Occupational-exposure;
Author Keywords: coal; epidemiologic methods; lung diseases; obstructive; occupational diseases; occupational exposure
Dr Noah S Seixas, Department of Environmental Health, SC-34, University of Washington, Seattle, WA 98195
American Journal of Epidemiology
University of Michigan at Ann Arbor, Ann Arbor, Michigan