Cytoskeletal proteins and axonal neuropathies.
Comments Toxicol 1989 Jan; 3(5):427-444
This review discussed neurofilamentous neuropathies and organophosphorus compound induced delayed neurotoxicity. A brief discussion was presented of the cytoskeletal proteins including microtubules, intermediate filaments, and microfilaments. The microfilaments are present in the peripheral areas in the axon and dendritic spines, usually in close association with plasma membrane. Microtubules are found in the cell center while neurofilaments may be centrally or peripherally located. The distribution of cytoskeletal proteins in peripheral nerves was discussed. Many of the most widely studied neurotoxicants produce a characteristic accumulation of neurofilaments. The accumulation may occur in the cell body, in the initial segment of the axon, or in the middle to terminal regions of the axon. At least five hypotheses have been proposed to account for the axonal accumulation of neurofilaments produced by these compounds. These included pyrrole formation, inhibition of glycolytic enzymes, neurofilament crosslinking, neurofilament phosphorylation, and diminished proteolysis.
NIOSH-Grant; Neurotoxic-effects; Protein-chemistry; Protein-synthesis; Organo-phosphorus-compounds; Nervous-system-disorders;
Pharmacology Duke University Medical Center Box 3813 Durham, NC 27710
Neurotoxic Disorders; Neurotoxic-effects;
Comments on Modern Biology. Part B, Comments on Toxicology
Duke University, Durham, North Carolina