Triphenyl phosphite: a type II organophosphorus compound-induced delayed neurotoxic agent.
Organophosphates: chemistry, fate, and effects. Chambers JE, Levi PE, eds. Cambridge, MA: Academic Press, 1992 Jan; :327-351
The neurotoxicity of triphenyl-phosphite (101020) was studied. Following a brief discussion of phosphorus compounds and their chemical properties, including pentavalent and trivalent phosphorus containing compounds, specific attention was directed toward the action of organophosphorus esters. Acute toxicity is produced by these compounds through the inhibition of acetylcholinesterase (AChE), which is the enzyme responsible for hydrolyzing the neurotransmitter acetylcholine (ACh). Poisoning by organophosphorus compounds results in the accumulation of ACh in the central nervous system, creating tension, anxiety, restlessness, insomnia, headache, emotional instability, excessive dreaming, and nightmares. In addition to inhibiting AChE, some of these compounds produce a condition known as organophosphorus compound induced delayed neurotoxicity. Triaryl phosphites were reviewed with topics including acute convulsion action, in-vitro hydrolysis, differential neurotoxic actions of triphenyl phosphites resulting from differential routes of administration, neuropathological changes, the effect of age on sensitivity of chickens to triphenyl-phosphite induced delayed neurotoxicity, and the biochemical action.
NIOSH-Grant; Neurotoxic-effects; Nervous-system-disorders; Neuropathy; Laboratory-animals; Agricultural-chemicals; Organo-phosphorus-compounds; Organo-phosphorus-pesticides
Pharmacology Duke University Department of Pharmacology Durham, N C 27710
Chambers JE; Levi PE
Neurotoxic Disorders; Neurotoxic-effects
Organophosphates: chemistry, fate, and effects
Duke University, Durham, North Carolina