Monitoring styrene neurotoxicity with 3H-spiperone binding in lymphocytes.
Checkoway H; Costa LG; Coccini T; Rappaport S; Manzo L
Occupational Epidemiology: Proceedings of the Seventh International Symposium on Epidemiology in Occupational Health, Tokyo, Japan, October 11-13, 1989. Sakurai H, Okazaki I, Omae-K, eds., New York: Excerpta Medica, 1990 Jun; :197-200
The utility of monitoring tritium labeled spiperone (SP) binding in lymphocytes of workers exposed to styrene (100425) as a marker of neurotoxicity was determined. Thirty eight workers from a facility that manufactured luxury yachts and 17 nonexposed blood donor referents were studied. Seven exposure monitoring surveys were conducted at the site at roughly 6 week intervals. Personal samples were collected over the entire shift and analyzed by gas chromatography. Eight hour time weighted exposure at the site ranged from less than 1 to 91 parts per million (ppm). The median tritium labeled SP binding was greater among the workers than the volunteers, 67 versus 57 femtomoles/10(6) lymphocytes. Comparisons between workers grouped according to exposure level were given separately for males and females, and workers' styrene levels were averaged. No discernible trend was noted among the men. Female workers, however, demonstrated an increased tritium labeled SP binding with increased exposure levels. The authors stress that it would be beneficial to develop a noninvasive technique for monitoring exposures to neurotoxic chemicals, and that tritium labeled SP binding in lymphocytes appears to offer promise along these lines.
NIOSH-Grant; Neurotoxic-effects; Blood-cells; Biological-monitoring; Blood-analysis; Nervous-system-disorders; Sex-factors; Humans; Occupational-exposure; Boat-manufacturing-industry
Environmental Health University of Washington Dept/environmental Hlth/sc-34 Seattle, WA 98195
Sakurai-H; Okazaki-I; Omae-K
Neurotoxic Disorders; Neurotoxic-effects
Occupational Epidemiology: Proceedings of the Seventh International Symposium on Epidemiology in Occupational Health, Tokyo, Japan, October 11-13, 1989
University of Washington, Seattle, Washington