Subchronic toxicity of aniline hydrochloride in rats.
Khan-MF; Kaphalia-BS; Boor-PJ; Ansari-GA
Arch Environ Contam Toxicol 1993 Apr; 24(3):368-374
The interrelationship of blood changes, especially erythrocytes, with splenic lesions as a function of time after subchronically exposing male Sprague-Dawley-rats to aniline-hydrochloride (142041) (AH) was studied. Rats were exposed through their drinking water for up to 90 days and changes noted in the blood, spleen, and other tissues at days 30, 60, and 90. AH treatment caused decreases in the erythrocyte numbers, hemoglobin content and hematocrit values, but these decreases did not show any severity with the progression of exposure. Erythrocyte damage and splenic toxicity were closely associated processes and the progression of splenic lesions was dependent on the duration of the exposure. The iron content in the spleens of AH treated rats increased significantly with the progression of the exposure, probably due to deposition of chemically damaged erythrocytes. The iron overload may result in the generation of iron catalyzed free radicals which can cause oxidative damage to the spleen. The authors conclude that a good relationship exists between damage to erythrocytes and splenic lesions associated with aniline exposure.
NIOSH-Publication; NIOSH-Grant; Grants-other; Amines; Blood-cells; Blood-analysis; Spleen-disorders; Splenic-tissue; Laboratory-animals
Human Biol Chem and Genetics University of Texas Med BR Dept of Human Biol Chem&gene Galveston, Tex 77550-2774
Other Occupational Concerns; Grants-other
Archives of Environmental Contamination and Toxicology
University of Texas Medical Branch, Galveston, Texas