Airway hyperresponsiveness due to cotton bract extract.
Schachter EN; Witek TJ Jr.; Godbold J; Rienzi N; Buck MG; Lehnert BE; Zuskin E; Siegel J; Russomanno J; Fein E
Department of Internal Medicine, Mount Sinai School of Medicine, New York, New York 1992 Nov; :1-69
Studies were conducted to determine both the effect of previous cigarette smoking on cotton bract extract (CBE) hyperresponsiveness and the effect of repeated challenge with CBE to healthy persons who were not cigarette smokers. In the first part of the study, airway reactivity to methacholine was investigated before and after inhaling CBE in 28 nonsmokers and 50 smokers. On the day following baseline measurement of airway reactivity to methacholine, the study subjects first inhaled CBE. Significant drops in lung function were determined in nine of the 28 nonsmokers and 27 of the 50 smokers. A second study was also conducted in which 27 nonsmokers were studied to determine their reaction to inhalation challenge with CBE. Subjects were challenged with CBE on five consecutive days and again after 2 days. Airway reactivity to methacholine was determined 90 minutes after CBE challenge. Lung function decline was accentuated on day one and eight in the nonsmokers undergoing repeated daily challenge with CBE. This was not found on days two through five. The authors conclude that inhalation of CBE causes a characteristic initial airway response in healthy nonsmoking individuals. This response was reduced as exposure was repeated; bronchospasm recurred after a period of no challenge. Post bronchospasm hyperreactivity to methacholine was induced by CBE in responders. Airway reactivity was enhanced by smoking and the response to CBE was accentuated. The authors also conclude that the amount of smoking a worker did was not in any way related to the enhanced reactivity of CBE so that an index might be developed.
NIOSH-Grant; Pulmonary-system-disorders; Plant-dusts; Respiratory-system-disorders; Cotton-dust; Byssinosis; Humans; Cigarette-smoking; Pulmonary-function
Medicine Mount Sinai Medical Center One Gustave L Levy Place New York, N Y 10029
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Department of Internal Medicine, Mount Sinai School of Medicine, New York, New York
Mount Sinai School of Medicine, New York, New York