Excess hepatobiliary cancer mortality among munitions workers exposed to dinitrotoluene.
Stayner-LT; Dannenberg-AL; Bloom-T; Thun-M
J Occup Med 1993 Mar; 35(3):291-296
A retrospective cohort mortality study of workers exposed to dinitrotoluene (121142) (DNT) at a munitions facility was conducted. The study population was identified from current and former white male workers employed at a US Army munitions facility in Radford, Virginia. Subjects had worked at the facility for at least 5 months between 1949 and 1980. There were 4,989 workers in the exposed group and 7,436 workers in the nonexposed group. Vital status was determined as of 1982. Overall cancer mortality was less than expected for both the DNT exposed and the nonexposed groups. A borderline significance was noted for excess cancer of the biliary passages, liver and gall bladder. Hepatobiliary cancer mortality was greatest among workers over 70 years of age. Hepatobiliary cancer risk was greatest among DNT exposed workers 10 to 19 years after their first exposure and lowest among workers 20 years after their first exposure. No evidence of an increasing trend was found in hepatobiliary cancer mortality with duration of exposure. The primary cancer site was the liver in two cases, hepatic bile duct in two cases, and gall bladder with direct extension to the hepatic bile duct in one case. The authors suggest that their findings support the hypothesis that occupational exposure to DNT may be carcinogenic.
JOCMA7; NIOSH-Author; Epidemiology; Mortality-surveys; Carcinogens; Cancer-rates; Risk-factors; Munitions-industry; Nitro-compounds; Biliary-system-disorders; Occupational-exposure
Journal of Occupational Medicine