Strategies for the treatment of pneumoconiosis.
Banks-DE; Cheng-YH; Weber-SL; Ma-JK
Occup Med: State of the Art Rev 1993 Jan; 8(1):205-232
Following a brief review of the pathogenesis of silicosis, this report considered important aspects of therapies for pneumoconiosis which have been tried. There has been an aggressive search for therapeutic agents and procedures in China for silicosis and coal workers' pneumoconiosis. Various treatments for silicosis and coal workers' pneumoconiosis were discussed, including protection of the alveolar macrophage from silica (14808607) toxicity by using an aluminum-citrate complex of poly-2-vinylpyridine-N-oxide or poly-4-vinylpyridine-N-oxide (PVNO); control of the immune and inflammatory response through use of immunosuppressive and corticosteroid therapies; control of fibroproliferative activity through the use of tetrandrine or xinin; prevention of associated disease through the use of antimycobacterial therapy and pneumococcal vaccine; the removal of dust, macrophage and cytokines through whole lung lavage; lung transplantation; and monoclonal antibody therapy.
NIOSH-Publication; NIOSH-Cooperative-Agreement; Medical-treatment; Lung-disease; Respiratory-system-disorders; Lung-cells; Alveolar-cells; Coal-miners; Lung-fibrosis
Occupational Medicine: State of the Art Reviews. The Mining Industry
Center to Protect Workers' Rights