The immunotoxic potential of alachlor (15972608) was studied in rats. Male Fisher-344/N-rats were injected intraperitoneally with 1.24, 2.50, or 3.75mg/kg alachlor three times, with doses separated by intervals of 5 and 7 days. Dexamethasone was administered as a positive control. Delayed type hypersensitivity reactions to injection of keyhole-limpet-hemocyanin (KLH) were evaluated on days zero and seven by the footpad assay. Rats were killed on day 14 and the thymus, spleen, kidneys, and lungs were removed and weighed. The sera were assayed for humoral immunoglobulin-G antibodies raised against KLH and alachlor/bovine serum albumin conjugate. Splenic cell suspensions were prepared and assayed for natural killer cell activity against YAC-1 and EL-1 tumor cells. At 2.50mg/kg, alachlor caused a significant transient increase in body weight on day seven which disappeared by day 14. Alachlor did not significantly affect any of the immunological parameters or hematological variables evaluated. The authors conclude that the immunotoxic potential of alachlor in rats is minimal. Immunotoxicity is probably not a factor in the carcinogenicity of alachlor to rodents.
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