Pulmonary reactivity to vanadium pentoxide following subchronic inhalation exposure in a non-human primate animal model.
Knecht EA; Moorman WJ; Clark JC; Hull RD; Biagini RE; Lynch DW; Boyle TJ; Simon SD
J Appl Toxicol 1992 Dec; 12(6):427-434
The changes in pulmonary reactivity resulting from repeated vanadium- pentoxide (1314621) (V2O5) exposure were evaluated in monkeys. Adult, male cynomolgus-monkeys were exposed by inhalation for 6 hours/day, 5 days/week for 26 weeks to 0.1 to 1.1 milligram V2O5/cubic meter (mg/m3). One group was exposed to 0.1mg/m3 Monday, Wednesday, and Friday, and 1.1mg/m3 on Tuesday and Thursday. Another group was exposed to 0.5mg/m3, 5 days/week. Before exposure, challenge with V2O5 caused an impairment in pulmonary function. The airway obstruction was accompanied by a significant influx of inflammatory cells into the lung. Subchronic V2O5 inhalation did not produce an increase in V2O5 reactivity in comparison to the control group, and cytological, immunological and skin test results indicated the absence of allergic sensitization. A trend toward decreased pulmonary reactivity was found following subchronic V2O5 inhalation. Pulmonary reactivity to V2O5 was affected, as well as nonspecific reactivity to methacholine. The authors suggest that the absence of increased pulmonary reactivity to V2O5 following subchronic inhalation may be related to the induction of tolerance under the exposure conditions used in the study.
NIOSH-Author; Inhalation-studies; Laboratory-animals; Inhalants; Toxic-gases; Organic-vapors; Vanadium-compounds; Respiratory-system-disorders;
Author Keywords: vanadium pentoxide; pulmonary reactivity; subchronic inhalation exposure; provocation challenge; cynomolgus monkeys
Edwin A. Knecht, Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health. 4676 Columbia Parkway. Cincinnati, OH 45226, USA
Journal of Applied Toxicology