Enhanced inhibition of viral interferon induction by bioactivated aflatoxins.
J Environ Sci Health. Part A, Environ Sci Eng 1992 Dec; 27(8):2281-2299
The decrease of interferon induction by the influenza virus in mammalian cell monolayers was described. The contradistinction of effect on interferon's ability to provoke cellular resistance to viral infection by externally bioactivated B-series and G-series aflatoxins was also discussed. A structure/activity relationship was observed in the inhibition of interferon induction with decreasing potency occurring in the order of aflatoxin-B1 (1162658), aflatoxin-G1 (1165395), aflatoxin-B2 (7220817), and aflatoxin-G2 (7241987) by both nonactivated and bioactivated aflatoxins. To achieve 50% inhibition of interferon induction, the quantity of bioactivated aflatoxin of all types required was four times less than that of aflatoxins alone. Under all conditions relative to aflatoxin type and bioactivation status, there were dose/response relationships established between aflatoxin quantity and interferon inhibition. Higher levels of Sendai virus growth were noted in the nonactivated and bioactivated aflatoxin pretreated cells as opposed to the untreated cells. This activity was related to decreased production of interferon by aflatoxins. The ability of interferon to confer cellular resistance against viral infection was impaired by neither bioactivated nor nonactivated aflatoxins. The authors suggest that reactive metabolites are associated with the enhanced capability of bioactivating aflatoxins to inhibit viral induction of interferon-alpha/beta.
NIOSH-Author; Food-contaminants; Viral-diseases; Viral-infections; Bioactivation; Mammalian-cells; Mycotoxins
Dr. Nicholas Hahon, National Institutte of Occupational Safety and Health - ALOSH, 944 Chestnut Ridge Road, Morgantown, WV 26505-2888
1162-65-8; 1165-39-5; 7220-81-7; 7241-98-7
Journal of Environmental Science and Health. Part A: Environmental Science and Engineering