Teratological Evaluation of Rat Fetuses after Prenatal Exposure to Industrial Chemicals.
Intox Laboratories, Inc. 1984 Dec:212 pages
Rat fetuses were examined for teratological endpoints. The fetuses had been exposed to N,N-diethyl-m-toluamide (134623) (mDET), diethylene-glycol-monomethyl-ether (111773) (diEGME), or ethylene- glycol-monomethyl-ether (109864) (EGME), or were unexposed controls. No significant skeletal or visceral abnormalities were noted in rats exposed to mDET as compared to control animals. Exposure to diEGME caused several skeletal malformations and variations; the most common occurred in the ribs and included fused and/or wavy ribs and rudimentary cervical ribs. The percent of fetuses with skeletal variations increased in a dose related fashion. The most commonly observed visceral malformations were those of the cardiovascular system with 46% of the fetuses in the 2165mg/kg group having at least one malformation in this system. The percent of litters with at least one abnormal fetus in this study was 23% for the controls, 52% for the 720mg/kg group and 90% for the 2165mg/kg group. Administration of 50mg/kg EGME resulted in a significant increase in the percent of fetuses with visceral abnormalities. The most common malformations were those of the cardiovascular system.
NIOSH-Contract; Contract-200-84-2720; Glycols; Reproductive-hazards; Musculoskeletal-system-disorders; Cardiovascular-system-disorders; Laboratory-animals; Prenatal-exposure;
134-62-3; 111-77-3; 109-86-4;
Final Contract Report;
NTIS Accession No.
Musculoskeletal-system-disorders; Disease and Injury;
Intox Laboratories, Inc.