Occupational risks of pesticide exposure for females.
NIOSH 1992 Sep; :1-27
The effects of exposure to methoxychlor (72435) (MXC) on reproductive functions in nonpregnant and pregnant mice were studied. Sexually mature virgin female CD-I-mice were exposed to 1.25, 2.5, or 5.0 milligrams (mg) MXC via oral gavage for 5 consecutive days each week for either 2 or 4 weeks. A dose dependency of MXC was noted in inducing persistent vaginal estrus. Ovaries of MXC and estradiol-17beta (E-17beta) exposed mice weighed significantly less than controls. There was also an increase in the number of atretic large follicles in the E-17beta group and in those mice treated with the two highest doses of MXC, indicating a potential reduction in the immediate fertility of the mice. Increased lipid accumulation was noted in interstitial cells and theca cells of both E-17beta treated and 5.0mg MxC treated mice. This chemical appears to closely mimic the effects on the female ovary induced by estrogen and raises concern whether such an exposure of an adult female will interfere with the normal hormonal environment and thus jeopardize future pregnancy. These alterations appear to be reversible once exposure stops. Pregnant mice were exposed to 2.5, 5.0, or 7.5mg of MXC by gavage from day six to 15 of gestation. Mice exposed to 7.5mg MXC were not able to carry their litters to term. Results revealed a significant increase in the length of gestation of mice exposed to both E-17 beta and 5.0mg MXC. Females from a subsequent unexposed litter displayed a significant advance in time of vaginal opening, a residual effect of MXC from a mother exposed during a previous pregnancy.
NIOSH-Grant; Reproductive-system-disorders; Reproductive-effects; Reproductive-hazards; Laboratory-animals; Insecticides; Toxic-effects; Prenatal-exposure
Louisiana State University, School of Medicine, Department of Anatomy, 1901 Perdido Street, New Orleans, LA 70112
Final Grant Report
NTIS Accession No.
National Institute for Occupational Safety and Health
Louisiana State University, School of Medicine, Department of Anatomy, New Orleans, Louisiana