Paternal occupational lead exposure and congenital malformations.
Sallmen-M; Lindbohm-L; Anttila-A; Taskinen-H; Hemminki-K
J Epidemiol Community Health 1992 Oct; 46(5):519-522
The possibility that paternal occupational exposure to lead (7439921) may result in congenital malformations in children was examined. The study population was gathered from the records of men biologically monitored for inorganic lead exposure at the Institute of Occupational Health; the Central Population Register; the Finnish Register of Congenital Malformations; and the nationwide database on pregnancies in Finland. The final study population included 27 cases and 57 referents. Due to the small number of subjects and the low participation rate (67% among cases and 76% among referents), no firm conclusions were drawn. However, limited support for the effect of lead on congenital malformations was obtained. The odds ratio of congenital malformation for paternal lead exposure was increased, but not to the point of statistical significance. The authors suggest that current lead levels at workplaces may be detrimental to the reproductive health of affected men.
NIOSH-Publication; NIOSH-Grant; Reproductive-system-disorders; Lead-poisoning; Heavy-metal-poisoning; Reproductive-hazards; Epidemiology; Pregnancy
Indus Hygiene & Toxic Haartmaninkatu 1
Journal of Epidemiology and Community Health
Institute of Occupational Health, Helsinki, Finland