Occupational exposures and birth defects.
Slone Epidemiology Unit, Boston University School of Medicine, Brookline, Massachusetts 1992 May; :1-48
The utility of the job exposure matrix (JEM) of NIOSH in occupational teratogen research was assessed. Information was taken from the Slone Epidemiology Unit Birth Defects Study (BDS). The JEM was used to assign specific workplace exposures to the mothers and fathers of the 11,000 malformed infants in the BDS data file. BDS job title/industry codes were translated into codes compatible with the JEM. Computer software was developed to produce tabulations which provided frequencies of each listed exposure in each birth defect category as well as comparisons to the remaining categories of defects. A detailed exploration of certain aspects of the data was conducted involving the testing of a specific hypothesis. Neither the absolute attribution of exposure nor the assessment of exposure probability by the JEM provided a credible measure of exposure. The authors conclude that the NIOSH JEM cannot be usefully applied to the BDS data base to assess risks of occupational exposures in relation to birth defects.
NIOSH-Grant; Reproductive-system-disorders; Reproductive-hazards; Risk-analysis; Epidemiology; Occupational-exposure
Slone Epidemiology Unit Boston Univ Med/drug Epid Unit 1371 Beacon Street Brookline, MA 02146
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Slone Epidemiology Unit, Boston University School of Medicine, Brookline, Massachusetts
Boston University, Boston, Massachusetts