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Health hazard evaluation report: HETA-91-104-2229, Florida Hospital, Orlando, Florida.
Decker J; Shults RA
Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, HETA 91-104-2229, 1992 Jun; :1-48
In response to a request by hospital management to evaluate employee exposures to aerosolized ribavirin (36791045) (AR), an investigation was made at Florida Hospital (SIC-8062), Orlando, Florida. The hospital was an 801 bed medical center and teaching hospital. The investigation was conducted in the pediatric intensive care unit where AR was administered to infants and children. An aerosol containment device was used on most administrations of AR, and most health care workers used personal protective equipment as required by hospital policy. Urine samples (148) were collected from 44 health care workers and analyzed for ribavirin. Post shift urinary ribavirin concentrations equal to or above the limit of quantification of 0.01 micromole of ribavirin per liter of urine were found in 13 of 20 post shift urine samples from nurses and in three of 20 samples from respiratory therapists. Creatinine corrected post shift urinary ribavirin values ranged from less than mean of 0.017 micromole/gram. The mean post shift value for nurses was 0.030 micromole/gram while the mean for RTs was 0.004 micromole/gram.
NIOSH-Author; NIOSH-Health-Hazard-Evaluation; NIOSH-Technical-Assistance-Report; HETA-91-104-2229; Hazard-Confirmed; Region-4; Health-care-personnel; Nursing; Urinalysis; Biological-monitoring; Occupational-exposure; Pharmaceuticals; Author Keywords: General Medical and Surgical Hospitals; ribavirin; Virazole; 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboximide; aerosolized drugs; aerosolized pharmaceuticals; health care workers; aerosol containment system; urinary ribavirin
Field Studies; Hazard Evaluation and Technical Assistance
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National Institute for Occupational Safety and Health
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Content source: National Institute for Occupational Safety and Health Education and Information Division