Measures of depressed mood in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
The association between occupational exposure to 2,3,7,8- tetrachlorodibenzo-p-dioxin (1746016) (TCDD) and depression was investigated. NIOSH conducted a cross sectional medical study of 281 workers employed in producing 2,4,5-trichlorophenol or 2,4,5- trichlorophenoxyacetic-acid between 1951 and 1969 at a New Jersey plant or between 1968 and 1972 at a Missouri plant. A population of 260 unexposed individuals matched for age, race, and community were used as comparisons. The subjects were administered a battery of psychological tests including the Beck Depression Inventory and the depression subscale of the Self Report Symptom Inventory Revised 90. Serum TCDD levels were determined from blood tests. Occupationally exposed individuals had a mean serum TCDD level of 220 parts per trillion (ppt) compared to 6ppt for nonexposed referents. The unadjusted mean scores for the Beck Depression Inventory or the Self Report Symptom Inventory Revised 90 tests were not significantly different between the two groups. Linear regression and logistic regression adjustments found no significant associations between TCDD exposure and the two outcome variables. The authors conclude that exposure to TCDD is not associated with measures of depressed mood.