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A review of the gastrointestinal effects from exposure to substances contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Calvert G; Sweeney M; Fingerhut M; Halperin W
Chemosphere 1992 Jul; 25(1-2):243-246
The association between gastrointestinal effects and 2,3,7,8- tetrachloro-p-dioxin (1746016) (TCDD) exposure were reviewed by analyzing epidemiological studies. Two separate cross sectional population studies revealed statistically significant increases in self reported ulcers in subjects exposed to substances contaminated with TCDD. Conversely, a survey of US Air Force Ranch Hands did not find an increase of gastrointestinal disorders in individuals exposed to TCDD. NIOSH conducted a cross sectional study of occupational exposure to TCDD in workers employed in chemical plants. These groups of workers were exposed to sodium- trichlorophenol (1320792), 2,4,5-trichlorophenoxyacetic-ester, or hexachlorophene (70304). Worker interviews and serum TCDD levels indicated that these subjects had high exposure to TCDD. Data from this study were used to assess the association between TCDD exposure and gastrointestinal disorders. The authors conclude that the effects of TCDD exposure on the liver and gastrointestinal system have not been consistently supported by epidemiological studies.
NIOSH-Author; Epidemiology; Gastrointestinal-system-disorders; Hepatotoxicity; Humans; Occupational-exposure; Polychlorinated-aromatic-hydrocarbons; Toxic-effects
1746-01-6; 1320-79-2; 70-30-4
Issue of Publication
Page last reviewed: September 22, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division