Response to and defense of a study on bladder cancer in workers exposed to aniline (62533) were presented. The authors of the original study concluded that ortho-toluidine (95534), not 4- aminobiphenyl (92671), was the major carcinogen underlying the excess incidence of bladder cancer in workers involved in antioxidant manufacturing. Opposition focused on combined evidence favoring 4-aminobiphenyl as the causative agent. Additional information to support the role of ortho-toluidine included: the known carcinogenicity of ortho-toluidine in both mice and rats; the massive quantities of ortho-toluidine used in the manufacture of the antioxidant; the high concentrations of ortho-toluidine observed in air samples and post shift urine samples from exposed workers; and the presence of only trace amounts of 4-aminobiphenyl in bulk samples amounting to less than one part per million. The ratio of the estimated TD50 of 4-aminobiphenyl to that of ortho-toluidine was also considered. The authors concluded that the weight of available evidence favors ortho-toluidine as the major etiologic agent in the excess incidence of bladder cancer.
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