Reproductive toxicity of ethylene glycol monomethyl ether, ethylene glycol monoethyl ether and their acetates.
Scand J Work, Environ & Health 1992 Jun; 18(Suppl 2):43-45
Studies on animals concerning the reproductive and developmental hazards of ethylene-glycol-monomethyl-ether (109864) (EGME), ethylene-glycol-monoethyl-ether (110805) (EGEE), ethylene-glycol- monomethyl-ether-acetate (110496) (EGMEA), and ethylene-glycol- monoethyl-ether-acetate (111159) (EGEEA) were reviewed and discussed. Limited evidence suggested that EGME, EGEE or their acetates cause adverse effects on the male reproductive system in humans. Treating pregnant females of various animal species with EGME, EGEE, or EGEEA has resulted in decreased body weight and body weight gain, prolonged gestation and a significantly increased mean number and percentage of resorptions and infertility. After reviewing the evidence concerning EGME and EGEE, NIOSH recommended that exposure to these glycol ethers be minimized in the workplace. OSHA announced in 1987 a notice of intended change for EGME, EGEE and their acetates and the agency was engaged in rule making for these chemicals. NIOSH recommendations included exposure limits of average, 0.5ppm EGEE or EGEEA as a time weighted average, and prohibiting dermal contact with all four compounds.
NIOSH-Author; Toxic-effects; Reproductive-system-disorders; Glycols; Laboratory-animals; Standards; Reproductive-hazards
MsJA Wess, National Institute for Occupational Safety and Health, Division of Standards Development and Technology Transfer, Cincinnati, Ohio 45226-1998, USA
109-86-4; 110-80-5; 110-49-6; 111-15-9
Scandinavian Journal of Work, Environment and Health