Effects of parental occupational exposure to solvents and lead on spontaneous abortion.
Lindbohm-L; Taskinen-H; Kyyronen-P; Sallmen-M; Anttila-A; Hemminki-K
Scand J Work, Environ & Health 1992 Jun; 18(Suppl 2):37-39
Finnish studies on the possible relationship of parental occupational exposure to organic solvents or inorganic lead (7439921) to the incidence of spontaneous abortion were reviewed. Four groups of persons were studied: pharmaceutical factory workers, laundry and dry cleaning workers, and men and women biologically monitored for solvent exposure. The pregnancies of the workers or the wives of the male workers were identified from the nationwide database on births and spontaneous abortions treated in hospitals in Finland between 1973 and 1983. The odds ratio of spontaneous abortion for maternal exposure to solvents was increased among the pharmaceutical factory workers and significantly increased among the women monitored for solvents. For the individual solvents, high exposures to methylene-chloride (75092), tetrachloroethylene (127184), and aliphatic hydrocarbons were associated with spontaneous abortion. The odds ratio for toluene (108883) was elevated in a small group of shoe workers. Maternal exposure to lead was not associated with increased incidence of spontaneous abortion. Paternal exposure to organic solvents in general and high exposure to toluene and miscellaneous solvents such as thinners showed increased risk for spontaneous abortion.
NIOSH-Publication; NIOSH-Grant; Reproductive-system-disorders; Solvent-vapors; Reproductive-hazards; Pharmaceutical-industry; Dry-cleaning-solvents; Dry-cleaning-industry; Occupational-exposure; Heavy-metals
Dr ML Lindbohm , Institute of Occupational Health, Topeliuksenkatu41 a A, SF-00250 Helsinki, Finland
7439-92-1; 75-09-2; 127-18-4; 108-88-3
Scandinavian Journal of Work, Environment and Health
Institute of Occupational Health, Helsinki, Finland