Data gaps and new methodologies in the assessment of male fecundity in occupational field studies.
Scand J Work, Environ & Health 1992 Jun; 18(Suppl 2):30-32
Methods for evaluating the effects of potential toxicants on the human male reproductive system were discussed. Although semen analysis has been used to assess spermatogenesis and sperm cell and accessory gland function, toxicants may affect other phases of the reproductive system including the genetic integrity of the sperm cell, neuroendocrine function, and sexual function. Genetic damage may be assessed by sperm chromosome assays and DNA stability assays. Methods of study being developed by several laboratories include DNA stability assessment by flow cytometry (DNA/FC). The DNA/FC assay can provide information regarding genetic damage to nucleic acids. The reproductive neuroendocrine axis of a man involves primarily the central nervous system, the anterior pituitary gland, and the testes. A study has indicated that hormone levels can be evaluated using a single blood draw rather than by three blood draws for population based studies. Assessment of occupational exposure induced anomalies of sexual function has been difficult.
NIOSH-Author; Reproductive-system-disorders; Men; Genotoxic-effects; DNA-damage; DNA-adducts; Endocrine-function; Reproductive-hazards; Toxic-effects
Dr SM Schrader, NIOSH C-23, 4676 Columbia Parkway, Cincinnati, Ohio 45226-1998, USA
Scandinavian Journal of Work, Environment and Health