Use of biomarkers of occupational musculoskeletal disorders in epidemiology and laboratory animal model development.
Mastin-JP; Henningsen-GM; Fine-LJ
Scand J Work, Environ & Health 1992 Jun; 18(Suppl 2):85-87
The possibility that biomarker technology could be used to detect occupational musculoskeletal disease at an early, preclinical stage and allow intervention methods to be taken prior to irreversible damage occurring was discussed. Four types of biomolecules have been investigated as potential biomarkers of musculoskeletal disease: proteins that are constituents of musculoskeletal tissue and either released through catabolic processes or produced as part of the repair process; proteins associated with the inflammatory response; preinflammatory response biomolecules; and indicators of immune mediated inflammatory processes. While most musculoskeletal biomarkers are not specific for a particular disorder, they can be compatible with and aid in supporting the presence and extent of disease when used as part of a profile of appropriate tests and accurate work histories. Research in this area was being conducted to identify biomarkers of the early stages of experimental progressive joint disease in two animal models. Preliminary results have identified four potential biomarkers for immobilization induced joint disease: haptoglobin, beta2-microglobulin, cartilage matrix glycoprotein, and a 25 kilodalton glycoprotein.
NIOSH-Author; Musculoskeletal-system-disorders; Biological-monitoring; Preventive-medicine; Epidemiology; Laboratory-animals; Occupational-diseases; Cumulative-trauma-disorders
Dr JP Mastin, National Institute for Occupational Safety and Health, 4676 Columbia Park way, Cincinnati , OH 45226, USA
Scandinavian Journal of Work, Environment and Health