Response of the National Institute for Occupational Safety and Health to an occupational health risk from exposure to ortho- toluidine and aniline.
Ruder-AM; Ward-EM; Roberts-DR; Teass-AW; Brown-KK; Fingerhut-MA; Stettler-LE
Scand J Work, Environ & Health 1992 Jun; 18(Suppl 2):82-84
A health hazard evaluation had been requested by union members regarding possible hazardous exposures at a New York chemical facility as there was an apparent increase in bladder cancer incidence among the rubber additives workers at the site. Nine cases had been diagnosed from 1973 to 1988. Of the several chemicals to which these workers were exposed, only o-toluidine (95534) was classified as an animal carcinogen. An epidemiological study of cancer incidence was conducted, and biomonitoring was used to evaluate exposures. The results of the investigation demonstrated that there was a significant risk of bladder cancer occurring among workers considered to have definite exposure to o- toluidine and aniline (62533), and an intermediate risk among workers considered to have possible exposure. The risks among those definitely exposed increased with length of exposure and time since first exposure. Workers exposed had elevated levels of both chemicals in their urine before the workday began than did unexposed workers. By the end of the workday, these levels were ten to 40 times higher in the exposed workers. A study has recently been initiated by NIOSH to identify a cohort to study bladder cancer incidence among workers exposed only to o-toluidine. Information from the study was under evaluation.
NIOSH-Author; Biological-monitoring; Chemical-industry-workers; Urinalysis; Blood-analysis; Cancer-rates; Carcinogens; Epidemiology; Occupational-exposure; Bladder-cancer
DrAMRuder,NIOSH Taft Labs,Mailstop R-16, 4676 Columbia Parkway, Cincinnati, OH45226, USA
Scandinavian Journal of Work, Environment and Health