Biological monitoring for occupational exposures to ortho-toluidine and aniline.
Stettler-LE; Savage-RE; Brown-KK; Cheever-KL; Weigel-WW; DeBord-DG; Teass-AW; Dankovic-D; Ward-EM
Scand J Work, Environ & Health 1992 Jun; 18(Suppl 2):78-81
Biological monitoring methods developed for a NIOSH study of worker exposures to o-toluidine (95534) and aniline (62533) at a facility producing an antioxidant and an accelerator used in tire manufacturing were described. An excess of bladder cancers had been determined among workers at this facility which had been attributed to o-toluidine and aniline exposures. All of the methods developed to measure aniline and o-toluidine in the urine and human albumin relied on the measurement of free amines following base hydrolysis to convert acetylated metabolites in the urine or adducts back to the parent compounds. An analysis of worker urine clearly showed that the uptake of both aniline and o-toluidine occurred in the workplace. The data for o-toluidine were the most striking and indicated that exposed workers were absorbing o-toluidine during the workshift, as the average concentration in the postshift samples compared with the preshift samples was six fold higher.
NIOSH-Author; Urinalysis; Blood-analysis; Carcinogens; Analytical-methods; Chemical-industry-workers; Chemical-analysis; Biological-monitoring; Anilines
Scandinavian Journal of Work, Environment and Health