Peripheral markers of neurochemical function among workers exposed to styrene.
Checkoway-H; Costa-LG; Camp-J; Coccini-T; Daniell-WE; Dills-RL
Br J Ind Med 1992 Aug; 49(8):560-565
A study of the ability of peripheral blood cell markers to serve as biomarkers for the effects of styrene (100425) on neurochemical function was conducted. The cohort consisted of 60 persons, 44 males, 20 to 47 years old, employed at three fiberglass reinforced plastics factories in western Washington State. They were exposed to styrene concentrations of 1 to 160 parts per million. The comparisons consisted of 18 machine assembly workers not exposed to styrene. Each subject completed a questionnaire to obtain information on work related central nervous system (CNS) symptoms, biodemographic characteristics, job history, smoking, and alcohol consumption. Peripheral blood samples were collected and analyzed for styrene and platelet monoamine-oxidase-type-B (MAOB) activity, lymphocyte sigma receptor binding, and serotonin uptake by platelets, which were used as markers of neurochemical function. Seventeen exposed subjects had blood styrene concentrations below concentrations of 0.05 to 0.19microg/ml, and 10 had blood styrene concentrations of 20microg/ml or greater. The prevalences of headache, dizziness, fatigue, irritation, memory loss, and feeling drunk were positively, significantly associated with blood styrene concentration. The degree of sigma receptor binding was not associated with blood styrene concentration. A weak positive association between platelet serotonin uptake and blood styrene concentration was observed. MAOB activity was strongly, inversely associated with blood styrene concentration. MAOB activity was also significantly, inversely associated with the prevalence of CNS symptoms. The authors conclude that MAOB activity may be a useful biomarker of styrene neurotoxicity.
NIOSH-Publication; NIOSH-Grant; Neurotoxic-effects; Organic-solvents; Aromatic-hydrocarbons; Occupational-exposure; Reinforced-plastics; Plastics-industry; Blood-samples; Enzyme-activity; Biochemical-indicators
Environmental Health University of Washington Dept/environmental Hlth/sc-34 Seattle, WA 98195
Neurotoxic Disorders; Neurotoxic-effects
British Journal of Industrial Medicine
University of Washington, Seattle, Washington