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Mortality of workers employed at organochlorine pesticide manufacturing plants - an update.
Scand J Work Environ Health 1992 Jun; 18(3):155-161
A mortality study on the carcinogenic risk among workers exposed to various organochlorine pesticides was updated from 1976 through 1987. The original study had included white male workers employed for at least 6 months before 31 December 1964 at the four facilities. The workers at the four facilities exposed to the following chemicals: chlordane (57749); heptachlor (76448) and endrin (72208); aldrin (309002), dieldrin (60571), endrin, and dibromochloropropane (96128) (DBCP); and dichlorodiphenyltrichloroethane (50293) (DDT). Four study groups were formed, one from each of the four facilities. The findings supported the possibility of a carcinogenic effect of exposure to organochlorine pesticides. The most important finding was a statistically significant increase in liver and biliary tract cancer among workers at the facility where aldrin, dieldrin, endrin and DBCP were produced. A nonsignificant increase in liver and biliary tract cancer was also noted at the facility where DDT was produced. The lack of exposure data limited the study.
NIOSH-Author; Organo-bromine-compounds; Agricultural-chemicals; Chemical-manufacturing-industry; Mortality-data; Chemical-industry-workers; Organo-chlorine-compounds; Cancer-rates; Risk-factors; Epidemiology; Mortality-surveys; Author Keywords: aldrin; cancer; chlordane; dichlorodiphenyltrichloroethane; dieldrin; epidemiology; heptachlor; liver cancer; organochlorine pesticides
Mr DP Brown, Office of Occupational Health and Technical Services, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
57-74-9; 76-44-8; 72-20-8; 309-00-2; 60-57-1; 96-12-8; 50-29-3
Issue of Publication
Scandinavian Journal of Work, Environment & Health
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division